CPI 0610 ( CPI0610 )

产品货号. M12851 CAS No. 1845726-14-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CPI 0610
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay.
产品描述

CPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay; shows remarkably selectivity, over the bromodomains of CBP, BRD9, BRPF1, PCAF, BRG1, ATAD2, TRIM24, BRD8; has an IC50 of 0.18 uM in MYC RNA expression assay; demonstrates antitumor efficacy in an MV-4-11 mouse xenograft model.
同义词

CPI0610
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1845726-14-8
分子量

365.82
分子式

C20H16ClN3O2
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[e]isoxazolo[5,4-c]azepin-4-yl)acetamide

1. Albrecht BK, et al. J Med Chem. 2016 Feb 25;59(4):1330-9.
2. Siu KT, et al. Leukemia. 2017 Jan 3. doi: 10.1038/leu.2016.355.

计算器

产品手册

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